Long time readers may be aware that I've dabbled in the NIH game a bit in my wayward youth. In this effort I've had mixed success - one proposal landing 1%ile out of funding and two triaged. My last round of NIH reviews was particularly blunt in slapping me with some language to the effect of "You should learn to write for NIH before you resubmit", so I have concentrated on diversifying my NSF portfolio since last slinking away to lick my wounds.
In October I'm planning on submitting an R21 to support an off-shoot of a core project. I'm taking it in an unusual direction for me that aligns better with NIH and the R21 mechanism is, on paper just right for the proposal. That is because the R21 mechanism is geared towards limited support ($275k direct) for a short (2 year) and "risky" project. This mechanism was NIH's response to criticism that it only funds safe and proven projects that result in incremental science.
The idea, of course, is to get into the NIH system and generate data that would lead to an R01 proposal in a couple of years. I'm sure this is the intention of most people opting for an R21.
The numbers that Datahound churned up are a bit sobering with regard to future NIH success for R21 award winners. Although he's quick to point out the small sample size, it's very interesting that 72% of those with only R21 support in 2009 had no NIH money in 2013. Out of those who still had NIH money, 10% only had another R21. This suggests that the transition from R21 to R01 support is not all that common.
Why is that? There's several possible reasons. Certainly the smaller nature and shorter application (6 pages) of the R21 may be more attractive to PIs are smaller institutions. Perhaps the focus on the R21 takes away from landing the R01, stunting the progress of some labs. Maybe most R21 holders have no intention of taking the next step, but simply subsidize other funding with the R21. I don't know the answer and it would be damn near impossible to sort through all those (and other) options.
I'm sure the truth lays somewhere in between them all.
For those of you who have applied for an R21, why did you apply for that mechanism? Did/do you intend to shoot for an R01? If not, why not?